Adolfo Ferrando, MD, PHD

Research Faculty

Academic Title(s)

  • Associate Professor of Pediatrics and Pathology
  • Director, WOLF Foundation Leukemia/Lymphoma Laboratory

Education & Training

Medical School

University of Oviedo, Spain

Residency

Hospital Central de Asturias

Fellowship

Dana Farber Cancer Institute

Interests/Specialties

Pediatric Leukemia and Lymphoma

Research & Grants

Go to Publications

Faculty Statement

My laboratory works on the genetic and molecular basis of T-cell acute lymphoblastic leukemia (T-ALL) using a combination of genomic technologies, biochemical and genetic analysis. Over the last 10 years we have successfully used an integrated approach to define a critical role for NOTCH1 and the TLX1 and TLX3 oncogenes in the development of T-ALL. In addition we have identified and functionally characterized numerous genes that are mutated in patients with T-ALL and lymphoma including PTEN, WT1, PHF6, BCL11B, ETV6, EZH2 and NT5C2. My group has defined a role for these mutations in the development of resistance to conventional drug treatments and are in the process of using this knowledge to identify new treatments that can target these abnormalities. Our laboratory is funded by grants from the NIH, the Leukemia and Lymphoma Society and other private foundations.