James H. Garvin Jr., MD

Oncology; Stem Cell Transplantation

Academic Title(s)

  • Professor of Pediatrics at CUMC

Education & Training

  • Internship
    Children’s Hospital of Philadelphia
  • Residency
    Children’s Hospital of Philadelphia
  • Fellowship
    Dana-Farber Cancer Institute, MA
  • Medical School
    Thomas Jefferson University Medical College

Interests/Specialties

Conditions

Research & Grants

Go to Publications

Faculty Statement

I am a board-certified pediatric hematologist/oncologist specializing in the area of pediatric neuro-oncology (brain and spinal cord tumors). I’m also a member of the pediatric stem cell transplant team. My interest in the field of pediatric hematology/oncology began when I was in medical school, where I conducted laboratory research in pediatric hematology, and began to think about pursuing a career in this specialty. Today I’m gratified to provide our patients with treatments based on the latest medical research and best clinical practices. 

I serve as medical director of pediatric neuro-oncology, and work closely with our pediatric neurosurgeons, radiotherapists, radiologists, and pathologists. We care for children and adolescents with a variety of benign and malignant brain tumors, and meet weekly to review their progress. Increasingly, we use advanced molecular diagnostic techniques to characterize tumors and guide treatment. I have a particular interest in ependymoma, and led a national study of ependymoma treatment through the Children’s Oncology Group. I’m currently collaborating with investigators at the National Cancer Institute on a new treatment for high grade astrocytomas and brainstem gliomas. I’ve also worked with our neurosurgeons to pioneer the direct administration of chemotherapy into aggressive pediatric brain tumors by the technique of convection enhanced delivery, which was initially devised for use in recurrent brain tumors of adults.

In the area of pediatric blood and marrow stem cell transplant, I provide inpatient and outpatient care for children and adolescents with a variety of recurrent cancers and life-threatening non-cancer conditions such as severe aplastic anemia. I have a particular interest in metabolic and neurologic disorders that are potentially curable by allogeneic stem cell transplant (from an unaffected donor). I’ve completed a trial of risk-adapted transplant for severe aplastic anemia. I also incorporate autologous stem cell transplant into the treatment of infants with brain tumors, to facilitate the use of intensive chemotherapy as a means of avoiding or deferring radiotherapy.

My interests extend to symptom control, infectious complications, quality of life, and neuro-cognitive outcomes. These aspects of my work involve further collaboration with other pediatric specialists. Examples include conducting a study of antifungal prophylaxis through the Pediatric Blood & Marrow Transplant Consortium, and reporting on neurobehavioral outcomes in infant brain tumor patients receiving radiation-sparing treatment.  

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